This article has been cited by other articles in PMC. Over the years, many medications have been used to manage obesity but most of them are now withdrawn due to their serious adverse effects [ 5 ].
Galactomannan consist of linear chains of 1—4 diequatorially linked D-mannose residues; some contain single-sugar side chains of D-galactose attached by 1—6 glycosidic bonds [ 11 ]. Introduction Obesity is defined as an excess of white adipose tissue, which is associated with a higher risk of developing diabetes and cardiovascular disease.
As shown in Figures 5a and bthe administration of 0. According to a previous study, 19 this morphological change might partially be the dyslipidemia induced by high-fat diet of a higher monacolin K content, although the phenomenon was not observed in undifferentiated preadipocytes or in fully differentiated adipocytes subjected to the same RMR-E treatment.
The effects of diet on adipose tissue characteristics are shown in Table 3. No significant differences in cell numbers in either type of adipose tissue were noted between the diet groups. The 0. Design and measurements: To assess whether lipoprotein uptake and metabolization can account for the hypolipidemic effects of GSPE, LPL expression was analyzed in both muscle and adipose tissue.
Table 2: Department of Pharmacology, K. It appears that the increased size rather than number of adipocytes contributed to the increase in fat mass in the HF group. Jeon et al. The functional ingredients and the mechanism of action of RMR should be determined in future studies.
These findings demonstrated the preventive effect of AqE-TFG on fat accumulation and dyslipidemia, due to inhibition of impaired lipid digestion and absorption, in addition to improvement in glucose and lipid metabolism, enhancement of insulin sensitivity, increased antioxidant defense, and downregulation of lipogenic enzymes.
Lipolysis was estimated as the amount of glycerol released in the medium from 0. However, looking to structural similarity with the presently known Melanocortin-4 MC-4 agonists, involvement of MC-4 receptors in its activity can be guessed.
The rats were divided into four groups of six animals each. This presumption should be tested in future experiments. Lovastatin is a competitive inhibitor of HMG-CoA reductase, the major rate-limiting enzyme in the cholesterol biosynthesis pathway, which has been introduced to the clinic for the treatment of hypercholesterolemia.
The TG content within cells reflects the balance between lipogenesis and lipolysis, which is also responsible for the determination of cell size. Table 1: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
At the beginning of differentiation, 3T3-L1 preadipocytes undergo one or two additional rounds of cell division known as clonal expansion. Liver, muscle and adipose tissue were used to study the expression of genes involved in the synthesis and oxidation of fatty acids and lipoprotein homeostasis by real-time RT-PCR.
Cell proliferation was determined by MTT at 24 and 48 h after incubation. The cafeteria diet is a feeding regime in which animals are offered a choice of several palatable food items of varied composition, appearance and texture in addition to their normal chow diet.
The lipid weight of the average fat cell was calculated from the mean cell volume, assuming a lipid density of 0.Sep 16, · Red mold rice prevents the development of obesity, dyslipidemia and hyperinsulinemia induced by high-fat diet Skip to main content Thank you for visiting vsfmorocco.com by: Male Sprague Dawley rats were fed high-fat diet (HFD) for the first eight weeks, to develop obesity-induced dyslipidemia.
Later on piperine (40 mg / kg) and sibutramine (5 mg / kg) were administered for three weeks along with the continuation of HFD to two separate groups, which served as the test.
Jul 07, · GSPE treatment prevents dyslipidemia induced by high-fat diet. The body weight of rats fed with an HFD was significantly higher (approximately 40%) than those in the control group ().After 13 Cited by: Nov 03, · In this study, we examined the role of miR in the cardiac and metabolic alterations promoted by high fat (HF) diet.
We found that loss of miR attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be vsfmorocco.com by: 3.
Apr 29, · The correlation found between dyslipidemia and oxidative stress in this study shows that dyslipidemia induced by ingestion of high fat diet is the primary cause of lipid peroxidation.
Therefore, the possible reason for improvement in dyslipidemia with AqE-TFG may be due to reduction in oxidative stress in HFD fed rats. Objective. We previously found that lipoic acid (LA) improved high-fat diet (HFD)–induced dyslipidemia in rats.
To elucidate the molecular mechanisms of that effect, we carried out experiments aimed at analyzing biochemical parameters and gene expression vsfmorocco.com by: